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Pineapple Express is a sativa-dominant hybrid cannabis strain made by crossing Trainwreck with Hawaiian. While this strain rose to fame on the silver screen in 2008 amidst the release of Pineapple Express, it is a real strain that you can find on the shelves of dispensaries across the country. Since then, this strain has become a favorite in the hearts and minds of cannabis lovers. Pineapple Express produces long-lasting energetic effects that you can feel right away. may make you feel buzzy, alert, and creative. The best time to smoke Pineapple Express is in the morning, afternoon, or early evening hours.